Ishita Choudhary, Thao Vo, Kshitiz Paudel, Radha Yadav, Yun Mao, Sonika Patial, and Yogesh Saini. Postnatal ozone exposure disrupts alveolar development, exaggerates mucoinflammatory responses, and suppresses bacterial clearance in developing Scnn1b-Tg+ mice lungs. Accepted for publication in the Journal of Immunology (June, 2021).
Sonika Patial, Brandon W Lewis, Thao Vo, Ishita Choudhary, Kshitiz Paudel, Yun Mao, Dhruthi Singamsetty, Frank Brombacher, and Yogesh Saini. Myeloid IL-4Ra is an indispensable link in IL-33-ILCs-IL-13-IL4Ra axis of eosinophil recruitment in murine lungs. Accepted for publication in the Scientific Reports (July, 2021).
Ishita Choudhary, Thao Vo, Kshitiz Paudel, Radha Yadav, Richa Gupta, Mehmet Kesimer, Sonika Patial, and Yogesh Saini. Vesicular and extravesicular protein signatures from the airspaces of ozone-exposed mice reflect muco-inflammatory responses. Preprint available at in the Research Square. Awaiting resubmission to the Scientific Reports (2021.
Ishita Choudhary, Thao Vo, Chandra Bathula, Richa Lamichhane, Brandon Lewis, Jayme Looper, Samithamby Jeyaseelan, Yogesh Saini, and Sonika Patial. TTP overexpression in non-hematopoietic cells protects against acute lung injury in mice (2020). Front Immunol. 2020 Sep 2;11:2164.
Thao Vo, Kshitiz Paudel, Ishita Choudhary, Sonika Patial, and Yogesh Saini. Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2 (2020). Preprint published on bioRxiv (11th November, 2020).
Ishita Choudhary, Thao Vo, Kshitiz Paudel, Sonika Patial, and Yogesh Saini. Compartment-specific transcriptomics of ozone-exposed murine lungs reveals sex and cell type-associated perturbations relevant to mucoinflammatory lung diseases (2020). American Journal of Physiology Lung Cellular and Molecular Physiology, 2021 Jan 1;320(1):L99-L125.
Brandon W Lewis, Ishita Choudhary, Kshitiz Paudel, Yun Mao, Rahul Sharma, Yong Wang, Jessy S Deshane, Richard C Boucher, Sonika Patial, and Yogesh Saini. Innate lymphoid system is a critical player in the manifestation of muco-inflammatory airway disease in mice (2020). The Journal of Immunology. 2020 Sep 15;205(6):1695-1708.
Brandon W Lewis, Thao Vo, Ishita Choudhary, Allison Kidder, Chandra Bathula, Camille Ehre, Nobuko Wakamatsu, Sonika Patial, and Yogesh Saini. Ablation of IL-33 suppresses Th2 responses but is accompanied by sustained mucus obstruction in the Scnn1b transgenic mouse model (2020). The Journal of Immunology. 204(6): 1650-1660.
Yogesh Saini*, Brandon Lewis, Kristen Wilkinson, Hong Dang, Alessandra Livraghi-Butrico, Wanda K O’Neal, Richard C Boucher. Pulmonary macrophage depletion alters the lung pathology associated with defective mucus clearance. Physiological Reports, 2018 Apr;6(8):e13677. doi: 10.14814/phy2.13677. (*Corresponding Author). (Editor’s Choice Article, May 8, 2018)
Dongfang Yu, Yogesh Saini, Gang Chen, Ghio AJ, Hong Dang, Kimberly A. Burns, Yang Wang, RM Davis, Scott H Randell, Charles R Esther Jr, Fredrick Paulsen, Richard C Boucher. Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice. American Journal of Pathology 2018 Jan;188(1):95-110.
Brandon W Lewis, Razia, Sultana, Rahul Sharma, Alexandra Noël, Ingeborg Langohr, Sonika Patial, Arthur L Penn,Yogesh Saini. Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease. Journal of Immunology 2017 Aug 1;199(3):1170-1183. (Journal’s Issue Highlight)
Yogesh Saini, Steven P. Proper, Peter Dornbos, Krista K Greenwood, Anna K Kopec, Scott G Lynn, Elizabeth Grier, Lyle D Burgoon, Timothy R Zacharewski, Russell S Thomas, Jack R Harkema, John J LaPres. Loss of HIF2α rescues the HIF1α deletion phenotype of neonatal respiratory distress in mice. PLoS One. 2015 Sep 30;10(9):e0139270.
Yogesh Saini*, Kristen Wilkinson, Kristy Terrell, Kimberlie A Burns, Alessandra Livraghi-Butrico, Claire M Doerschuck, Wanda K O’Neal, Richard C Boucher. Neonatal pulmonary macrophage depletion coupled to defective mucus clearance alters pulmonary immune responses. American Journal of Respiratory Cell and Molecular Biology 2016 Feb;54(2):210-21. (*Corresponding Author).
Anand R Nair, Philip J Ebenezer, Yogesh Saini, Joseph Francis. Angiotensin II-induced hypertensive renal inflammation is mediated through HMGB1-TLR4 signaling in rat tubulo-epithelial cells. Exp Cell Res. 2015 Jul 15;335 (2):238-47.
Hyejin Hwang, Scott G Lynn, Ajith Vengellur, Yogesh Saini, EA Grier, SM Fergusan-Miller, John J LaPres. Hypoxia Inducible Factors (HIFs) modulate mitochondrial oxygen consumption and transcriptional regulation of nuclear encoded electron transport chain genes. Biochemistry. 2015 Jun 23;54(24):3739-48.
Yogesh Saini*, Hong Dang, Alessandra Livraghi-Butrico, E. Kelly, Lisa Jones, Wanda K O’Neal, Richard C Boucher. Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration. BMC Genomics 2014; 15:726. (*Corresponding Author).
Steven P Proper*, Yogesh Saini*, Krista K Greenwood, Lori A Bramble, Nathaniel J Downing, Jack R Harkema, John J LaPres. Loss of hypoxia-inducible factor 2 alpha (HIF2α) in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury. Toxicological sciences, 2014 February; 137(2):447-57. (*Equal Contribution)
Krista K Greenwood, Steven P Proper, Yogesh Saini, Daven N Jackson-Humbles, Jim G Wagner, Lori Bramble, Jack R Harkema, John J LaPres. Neonatal epithelial hypoxia inducible factor-1α expression regulates the lung’s response to experimental asthma. Am J Physiol Lung Cell Mol Physiol.2012 March; 302(5):L455-462.
Erica M Sparkenbaugh, Yogesh Saini, John J LaPres, Jane Maddox, PE Ganey and Robert A Roth. The role of hypoxia inducible factor-1 alpha (HIF-1α) in acetaminophen J Pharmacol Exp Ther. 2011 August; 338(2):492-502.
Sonika Patial, Shipra Shahi, Yogesh Saini, Daniel M Appledorn, John J LaPres, Andrea Amalfitano and Narayanan Parameswaran. G-protein coupled receptor kinase 5 (GRK5) regulates LPS induced NFκB pathway and is necessary for the production of pro-inflammatory cytokines and chemokines in LPS induced septic shock model of mice. Journal of Cellular Physiology, 2011 May; 226 (5):1323-33.
Sonika Patial, Yogesh Saini, Daniel M Appledorn, Gerald W Dorn, John J LaPres, Andrea Amalfitano, Patricia Senagore and Narayanan Parameswaran. Myeloid-specific GPCR kinase-2 negatively regulates NFκB1p105-ERK pathway and limits endotoxemic shock in mice. Journal of Cellular Physiology, 2011 March; 226 (3):627-37.
Yogesh Saini, Krista K Greenwood, Christian Merrill, Kyung Y Kim, Sonika Patial, Jack R Harkema, John J LaPres. Acute Cobalt-Induced Lung Injury and the Role of Hypoxia Inducible Factor 1α (HIF1α) in Modulating Inflammation.Toxicological sciences, 2010 August; 116 (2): 673-681.
Yogesh Saini, Kyung Y Kim, Lori Bramble, Ryan Lewandowski, Jack R Harkema, John J LaPres. Role of Hypoxia Inducible Factor 1 alpha (HIF1α) in cobalt-induced lung injury. Am J Physiol Lung Cell Mol Physiol.2010 February; 298(2):L139-47.
Yogesh Saini, Jack R Harkema, John J HIF1α is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. Journal of Biological Chemistry, 2008 November; 28; 283(48):33650-33657.
Sonika Patial, VK Chaturvedi, A Rai, M Saini, Rajesh Chandra, Yogesh Saini and Praveen K Gupta. Virus neutralizing antibody response in mice and dogs with a bicistronic DNA vaccine encoding rabies virus glycoprotein and canine parvovirus VP2. Vaccine, 2007 May; 25:4020-4028.
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